March 1, 2024
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Posterior vitreous detachment (PVD) by non-enzymatic reagents concentrating on vitreous collagen

Induction of posterior vitreous detachment (PVD) by non-enzymatic reagents concentrating on vitreous collagen liquefaction along with vitreoretinal adhesion

Induction of posterior vitreous detachment (PVD) by pharmacologic vitreolysis has been largely tried by the use of utilizing enzymatic reagents. Ocriplasmin has been the one FDA-approved scientific reagent so far. Various hostile outcomes of ocriplasmin have emerged, nonetheless, and the look for varied PVD-inducing reagents continues. Since i) collagen varieties a very important structural component of the vitreous, and ii) sturdy vitreoretinal adhesions exist between the cortical vitreous and the inside limiting membrane (ILM) of the retina, an environment-friendly PVD-inducing reagent would require every, vitreous liquefaction, and concurrent dehiscence of vitreoretinal adhesion, without being toxic to retinal cells. We designed a combination of two reagents to understand these two targets; a triple helix-destabilizing collagen-binding space (CBD), and a fusion of RGD (integrin-binding) tripeptide with CBD (RCBD) to facilitate separation of the posterior cortical vitreous from the retinal ground. Primarily based totally on in vitro, ex-vivo, and in vivo experiments, we current {{that a}} combination of CBD and RCBD exhibits potential for protected pharmacologic vitreolysis. Our findings assume significance in mild of the reality that synthetic RGD-containing peptides have already been used for inhibition of tumor cell invasion. Proteins just like variants of collagen-binding domains may need extended therapeutic makes use of in the end.
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Anti-Human LEC Goat Polyclonal Antibody

TA328365 100 µg Ask for price

Recombinant Human LEC (CCL16)

Z100325 25 µg
EUR 235
Description: CCL16 is a CC chemokine that specifically attracts lymphocytes, dendritic cells, and monocytes; increases their adhesive properties and has myelosuppressive activity. It is constitutively expressed in liver and is increased by interleukin 10 (IL-10) in activated monocytes. CCL16 is present in human plasma suggesting that it may be active outside hepatic tissue. CCR1, CCR2, CCR5, and CCR8 are the functional receptors of this chemokine.

Recombinant Human LEC (CCL16)

Z100329 1.0 mg
EUR 3900
Description: CCL16 is a CC chemokine that specifically attracts lymphocytes, dendritic cells, and monocytes; increases their adhesive properties and has myelosuppressive activity. It is constitutively expressed in liver and is increased by interleukin 10 (IL-10) in activated monocytes. CCL16 is present in human plasma suggesting that it may be active outside hepatic tissue. CCR1, CCR2, CCR5, and CCR8 are the functional receptors of this chemokine.

LEC antibody

10R-L115A 500 ug
EUR 240
  • Lyophilized from PBS.
Description: Mouse monoclonal LEC antibody

LEC antibody

70R-LG003 50 ug
EUR 312
  • Lyophilized from PBS, pH 7.2.
Description: Affinity purified Goat polyclonal LEC antibody

Biotinylated Anti-Human LEC Goat Polyclonal Antibody

TA328364 50 µg Ask for price

Recombinant Human LEC (CCL16) Protein

PROTO15467-1 20ug
EUR 380.4
Description: LEC is a CC chemokine that can signal through the CCR8 and CCR1 receptors. It is expressed in the liver, spleen, and thymus. LEC is chemotactic towards monocytes and lymphocytes but not neutrophils. Recombinant human LEC is an 11.2 kDa protein containing 97 amino acid residues, including the four conserved cysteine residues present in CC chemokines.

Human LEC Recombinant Protein Lyophilized

IHULECRLY5UG each
EUR 341
  • Wet Ice
Description: Human LEC Recombinant Protein Lyophilized

LEC Chemokine(LEC66) Antibody

BNC940066-100 100uL
EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC66), CF594 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNC940066-500 500uL
EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC66), CF594 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNC940067-100 100uL
EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC67), CF594 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNC940067-500 500uL
EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC67), CF594 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNCH0066-100 100uL
EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC66), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNCH0066-500 500uL
EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC66), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNCH0067-100 100uL
EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC67), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNCH0067-500 500uL
EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC67), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNUM0066-50 50uL
EUR 474
Description: Primary antibody against LEC Chemokine(LEC66), 1mg/mL

LEC Chemokine(LEC67) Antibody

BNUM0067-50 50uL
EUR 474
Description: Primary antibody against LEC Chemokine(LEC67), 1mg/mL

LEC Chemokine(LEC66) Antibody

BNC700066-100 100uL
EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC66), CF770 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNC700066-500 500uL
EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC66), CF770 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNC700067-100 100uL
EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC67), CF770 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNC700067-500 500uL
EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC67), CF770 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNC800066-100 100uL
EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC66), CF680 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNC800066-500 500uL
EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC66), CF680 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNC800067-100 100uL
EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC67), CF680 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNC800067-500 500uL
EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC67), CF680 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNC810066-100 100uL
EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC66), CF680R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNC810066-500 500uL
EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC66), CF680R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNC810067-100 100uL
EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC67), CF680R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNC810067-500 500uL
EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC67), CF680R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNC880066-100 100uL
EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC66), CF488A conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNC880066-500 500uL
EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC66), CF488A conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNC880067-100 100uL
EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC67), CF488A conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNC880067-500 500uL
EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC67), CF488A conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNC550066-100 100uL
EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC66), CF555 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNC550066-500 500uL
EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC66), CF555 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNC550067-100 100uL
EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC67), CF555 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNC550067-500 500uL
EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC67), CF555 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNC610066-100 100uL
EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC66), CF660R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNC610066-500 500uL
EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC66), CF660R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNC610067-100 100uL
EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC67), CF660R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNC610067-500 500uL
EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC67), CF660R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNC430066-100 100uL
EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC66), CF543 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNC430066-500 500uL
EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC66), CF543 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNC430067-100 100uL
EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC67), CF543 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNC430067-500 500uL
EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC67), CF543 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNC470066-100 100uL
EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC66), CF647 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNC470066-500 500uL
EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC66), CF647 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNC470067-100 100uL
EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC67), CF647 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNC470067-500 500uL
EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC67), CF647 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNC680066-100 100uL
EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC66), CF568 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNC680066-500 500uL
EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC66), CF568 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNC680067-100 100uL
EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC67), CF568 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNC680067-500 500uL
EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC67), CF568 conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNC050066-100 100uL
EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC66), CF405M conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNC050066-500 500uL
EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC66), CF405M conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNC050067-100 100uL
EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC67), CF405M conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNC050067-500 500uL
EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC67), CF405M conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNC040066-100 100uL
EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC66), CF405S conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNC040066-500 500uL
EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC66), CF405S conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNC040067-100 100uL
EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC67), CF405S conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNC040067-500 500uL
EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC67), CF405S conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNC400066-100 100uL
EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC66), CF640R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNC400066-500 500uL
EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC66), CF640R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNC400067-100 100uL
EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC67), CF640R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNC400067-500 500uL
EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC67), CF640R conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNCA0066-250 250uL
EUR 459.6
Description: Primary antibody against LEC Chemokine(LEC66), APC conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNCA0067-250 250uL
EUR 459.6
Description: Primary antibody against LEC Chemokine(LEC67), APC conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNCAP0066-100 100uL
EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC66), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNCAP0066-500 500uL
EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC66), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNCAP0067-100 100uL
EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC67), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNCAP0067-500 500uL
EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC67), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNCB0066-100 100uL
EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC66), Biotin conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNCB0066-500 500uL
EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC66), Biotin conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNCB0067-100 100uL
EUR 238.8
Description: Primary antibody against LEC Chemokine(LEC67), Biotin conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNCB0067-500 500uL
EUR 652.8
Description: Primary antibody against LEC Chemokine(LEC67), Biotin conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNCP0066-250 250uL
EUR 459.6
Description: Primary antibody against LEC Chemokine(LEC66), PerCP conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNCP0067-250 250uL
EUR 459.6
Description: Primary antibody against LEC Chemokine(LEC67), PerCP conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNCR0066-250 250uL
EUR 459.6
Description: Primary antibody against LEC Chemokine(LEC66), RPE conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC67) Antibody

BNCR0067-250 250uL
EUR 459.6
Description: Primary antibody against LEC Chemokine(LEC67), RPE conjugate, Concentration: 0.1mg/mL

LEC Chemokine(LEC66) Antibody

BNUB0066-100 100uL
EUR 250.8
Description: Primary antibody against LEC Chemokine(LEC66), Concentration: 0.2mg/mL

LEC Chemokine(LEC66) Antibody

BNUB0066-500 500uL
EUR 549.6
Description: Primary antibody against LEC Chemokine(LEC66), Concentration: 0.2mg/mL

LEC Chemokine(LEC67) Antibody

BNUB0067-100 100uL
EUR 250.8
Description: Primary antibody against LEC Chemokine(LEC67), Concentration: 0.2mg/mL

LEC Chemokine(LEC67) Antibody

BNUB0067-500 500uL
EUR 549.6
Description: Primary antibody against LEC Chemokine(LEC67), Concentration: 0.2mg/mL

Recombinant Human LEC/NCC-4 (CCL16)

7-01792 5µg Ask for price

Recombinant Human LEC/NCC-4 (CCL16)

7-01793 20µg Ask for price

Recombinant Human LEC/NCC-4 (CCL16)

7-01794 1mg Ask for price

Recombinant Human LEC/NCC-4 (CCL16)

HECCP-1601 5ug Ask for price

LEC protein

30R-AL013 20 ug
EUR 312
  • Supplied as a lyophilized powder.
Description: Purified recombinant Human LEC protein

HCC-4, LEC, NCC-4, CCL16, human

RC315-27 5ug
EUR 125.26
  • Product category: Proteins/Recombinant Proteins/Cytokines

Human LEC/NCC-4 (CCL16) Recombinant Protein

100-060 20 µg
EUR 196.35
Description: LEC is a CC chemokine that can signal through the CCR8 and CCR1 receptors. It is expressed in the liver, spleen, and thymus. LEC is chemotactic towards monocytes and lymphocytes but not neutrophils. Recombinant human LEC is an 11.2 kDa protein containing 97 amino acid residues, including the four conserved cysteine residues present in CC chemokines.

Human LEC/NCC-4 (CCL16) Recombinant Protein

100-060S 5 µg
EUR 92.4
Description: LEC is a CC chemokine that can signal through the CCR8 and CCR1 receptors. It is expressed in the liver, spleen, and thymus. LEC is chemotactic towards monocytes and lymphocytes but not neutrophils. Recombinant human LEC is an 11.2 kDa protein containing 97 amino acid residues, including the four conserved cysteine residues present in CC chemokines.

CCL16 LEC/NCC-4 Human Recombinant Protein

PROTO15467 Regular: 20ug
EUR 380.4
Description: CCL16 Human Recombinant produced in E.Coli is a non-glycosylated, Polypeptide chain containing 97 amino acids and having a molecular mass of 11.2 kDa. ;The CCL16 is purified by proprietary chromatographic techniques.

Anti-LEC/CCL16/HCC4 antibody

STJ16100997 100 µg
EUR 424.8

LEC Recombinant Protein

40-396-0005mg 0.005 mg
EUR 311.1
Description: LEC is a CC chemokine that can signal through the CCR8 and CCR1 receptors. It is expressed in the liver, spleen, and thymus. LEC is chemotactic towards monocytes and lymphocytes but not neutrophils. Recombinant human LEC is an 11.2 kDa protein containing 97 amino acid residues, including the four conserved cysteine residues present in CC chemokines.

LEC Recombinant Protein

40-396-002mg 0.02 mg
EUR 437.1
Description: LEC is a CC chemokine that can signal through the CCR8 and CCR1 receptors. It is expressed in the liver, spleen, and thymus. LEC is chemotactic towards monocytes and lymphocytes but not neutrophils. Recombinant human LEC is an 11.2 kDa protein containing 97 amino acid residues, including the four conserved cysteine residues present in CC chemokines.

LEC Antibody / HCC-4 / CCL16

RQ4655 100ug
EUR 356.15
  • 0.5mg/ml if reconstituted with 0.2ml sterile DI water
Description: Chemokine (C-C motif) ligand 16 (CCL16) is a small cytokine belonging to the CC chemokine family that is known under several pseudonyms, including Liver-expressed chemokine (LEC) and Monotactin-1 (MTN-1). This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for lymphocytes and monocytes but not for neutrophils. This cytokine also shows a potent myelosuppressive activity and suppresses proliferation of myeloid progenitor cells. The expression of this gene is upregulated by IL-10.

Applicability of ninhydrin as a fluorescent reagent for estimation of teicoplanin in human plasma using salting-out assisted liquid-liquid extraction methodology

The applicability of ninhydrin, a broadly used derivatizing reagent, for dedication of teicoplanin (TEIC) in its pure variety, pharmaceutical vials, and in human plasma was investigated. The supplied spectrofluorimetric methodology was based mostly totally on a condensation response between ninhydrin and the primary amine group present in TEIC (throughout the presence of phenylacetaldehyde) to produce a extraordinarily fluorescent product detected at 460 nm (λex ,390 nm). Calibration plots have been constructed throughout the focus range 60-600 ng mL-1 with an ideal correlation coefficient of 0.9998 and a low detection prohibit of 10.84 ng mL-1 . The technique was subjected to a bioanalytical validation analysis in keeping with US-FDA options. The proposed methodology was utilized for analysis of TEIC in industrial vials with extreme restoration end result 101.88 ± 1.11%. In addition to, the methodology was utilized successfully for detection of TEIC in human plasma using salting-out assisted liquid-liquid extraction methodology (SALLE) with a restoration range from 96.71 ± 1.08% to 97.71 ± 0.86%. SALLE is an environment friendly methodology used for extraction of TEIC from human plasma with out interferences using ammonium sulphate. The proposed methodology could be very advisable to observe TEIC in scientific laboratory samples and therapeutic drug monitoring strategies.

Evaluation of a model new thromboplastin reagent STA-NeoPTimal on a STA R Max analyzer for the measurement of prothrombin time, worldwide normalized ratio and extrinsic problem ranges

Introduction: We geared towards evaluating the effectivity of a model new prothrombin time (PT) reagent (STA-NeoPTimal) with two totally different PT reagents (STA-Neoplastine R and STA-Neoplastine CI Plus) and the reference PT reagent utilized in our laboratory (ReadiPlasTin). Methods: Evaluation consisted in intra- and interassay precision analysis, dedication of sensitivity to unfractionated heparin (UFH) or enoxaparin in spiked samples and to direct oral anticoagulants (DOACs) in victims (n = 43). Method comparability of the 4 PT reagents, problem II, V, VII and X assays was examined on common (n = 20) and irregular samples: VKA (n = 47), preoperative (n = 23), liver failure (n = 12) and burned victims (n = 37). Outcomes: Analytical effectivity met producers’ requirements for all reagents. All PT reagents gave correlation coefficients >0.eight and even >0.9 in plenty of situations. In some VKA samples, variations ≥ 0.5 INR fashions have been current in samples inside and above therapeutic ranges. For burned victims, PT correlations have been good nevertheless with some minimal bias (<5.0%) whereas problem assays gave very fixed outcomes (R > .eight and primarily >0.9). As anticipated, poor responsiveness of the PT to DOAC concentrations was seen with all four assays. Conclusion: The STA-NeoPTimal confirmed comparable effectivity to ReadiPlasTin, making it applicable for VKA administration, detection of issues II, V, VII, X deficiency and analysis of liver sickness coagulopathy. Nonetheless, for victims receiving VKA, some essential variations have been seen. We confirmed the dearth of the PT assay to detect residual DOAC concentrations. Lastly, burned victims outcomes confirmed that recombinant thromboplastins have been a lot much less delicate to problem deficiencies in comparison with extraction thromboplastins.

PE anti-human CD80

E16FHP080-025 25 tests
EUR 293.67
Description: Available in various conjugation types.

PE anti-human CD80

E16FHP080-050 50 tests
EUR 419.33
Description: Available in various conjugation types.

PE anti-human CD80

E16FHP080-100 100 Tests
EUR 629
Description: Available in various conjugation types.

Anti-Human CD80 Antibody

101-M315 100 µg
EUR 399
Description: B7-1(CD80) and B7-2, together with their receptors CD28 and CTLA4, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. Although both CTLA4 and CD28 can bind to the same ligands, CTLA4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the downregulation of the immune response. B7-1 is expressed on activated B cells, activated T cells, and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B7-2 is expressed at low levels on monocytes and can be upregulated through interferon gamma. B7-1 and B7-2 are both members of the Immunoglobulin superfamily.

APC anti-human CD80

E16FHA080-025 25 tests
EUR 411.67
Description: Available in various conjugation types.

APC anti-human CD80

E16FHA080-100 100 tests
EUR 975
Description: Available in various conjugation types.

FITC anti-human CD80

E16FHF080-025 25 tests
EUR 222.33
Description: Available in various conjugation types.

FITC anti-human CD80

E16FHF080-050 50 tests
EUR 317.67
Description: Available in various conjugation types.

FITC anti-human CD80

E16FHF080-100 100 Tests
EUR 496
Description: Available in various conjugation types.

Biotin anti-human CD80

E16FHB080-100U 100 μg
EUR 693.33
Description: Available in various conjugation types.

Purified anti-human CD80

E16FHU080-100U 100 μg
EUR 190.67
Description: Available in various conjugation types.

Purified anti-human CD80

E16FHU080-500U 500 μg
EUR 572
Description: Available in various conjugation types.

Mouse Anti Human Cd80 Monoclonal Antibody,RPE

CABT-46705MH 25 TEST
EUR 514.8

Mouse Anti Human Cd80 Monoclonal Antibody,FITC

CABT-46701MH 0.1 mg
EUR 795.6

Human T-lymphocyte activation antigen CD80 (CD80)

1-CSB-CF1054HU
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  • 1MG
  • 200ug
  • 500ug
  • MW: 32.8 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human T-lymphocyte activation antigen CD80(CD80) expressed in in vitro E.coli expression system

Human T-lymphocyte activation antigen CD80 (CD80)

1-CSB-MP004959HU1
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  • 100ug
  • 1MG
  • 200ug
  • 500ug
  • MW: 51.4 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human T-lymphocyte activation antigen CD80(CD80),partial expressed in Mammalian cell

anti- CD80 antibody

FNab09813 100µg
EUR 658.5
  • Recommended dilution: WB: 1:1000-1:4000
  • IHC: 1:50-1:500
  • Immunogen: CD80
  • Uniprot ID: P33681
  • Research Area: Immunology,
Description: Antibody raised against CD80

anti- CD80 antibody

FNab01500 100µg
EUR 658.5
  • Immunogen: CD80 molecule
  • Uniprot ID: P33681
  • Gene ID: 941
  • Research Area: Immunology, Cardiovascular, Signal Transduction
Description: Antibody raised against CD80

Mouse Anti Human Cd80 Monoclonal Antibody,RPE-Cy5

CABT-46707MH 2ml
EUR 920.4

Rabbit Anti Human CD80 Monoclonal Clone AOEH-3

IRBAHUCD80AOEH3C100UL each
EUR 496
  • Dry Ice
Description: Rabbit Anti Human CD80 Monoclonal Clone AOEH-3

Recombinant Human T-lymphocyte activation antigen CD80(CD80)

AP78203 each Ask for price
  • in vitro E.coli expression system

Recombinant Human T-lymphocyte activation antigen CD80 (CD80)

CSB-CF1054HU 371 mg Ask for price

Human CD80/ T-lymphocyte activation antigen CD80 ELISA Kit

E0441Hu 1 Kit
EUR 515
  • Sandwich
Description: CD28LG,CD28LG1,LAB7,Activation B7-1 antigen,BB1,CTLA-4 counter-receptor B7.1,B7,CD80

Human CD80(T-lymphocyte activation antigen CD80) ELISA Kit

EH0088 96T
EUR 681.12
  • Detection range: 78-5000 pg/ml
  • Uniprot ID: P33681
  • Alias: CD80/B7-1/T-lymphocyte activation antigen CD80
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 46.9pg/ml

Human CD80(T-lymphocyte activation antigen CD80) ELISA Kit

EKF57017-48T 48T
EUR 396.9

Human CD80(T-lymphocyte activation antigen CD80) ELISA Kit

EKF57017-5x96T 5x96T
EUR 2693.25

Human CD80(T-lymphocyte activation antigen CD80) ELISA Kit

EKF57017-96T 96T
EUR 567

Human CD80(T-lymphocyte activation antigen CD80) ELISA Kit

E39EH0088 96T
EUR 595

PE-Cy5 anti-human CD80

E16FHC080-025 25 tests
EUR 476.67
Description: Available in various conjugation types.

PE-Cy5 anti-human CD80

E16FHC080-100 100 tests
EUR 1083.33
Description: Available in various conjugation types.

PE-Cy7 anti-human CD80

E16FHN080-025 25 tests
EUR 520
Description: Available in various conjugation types.

PE-Cy7 anti-human CD80

E16FHN080-100 100 tests
EUR 1126.67
Description: Available in various conjugation types.

Mouse Anti-Human CD80 mAb

CM015-100ug 100ug
EUR 224.4

Mouse Anti-Human CD80 mAb

CM015-25ug 25ug
EUR 146.4

NE Purified anti-human CD80

E16FHY080-050U 50 μg
EUR 433.33
Description: Available in various conjugation types.

NE Purified anti-human CD80

E16FHY080-500U 500 μg
EUR 1256.67
Description: Available in various conjugation types.

Human T- lymphocyte activation antigen CD80, CD80 ELISA KIT

ELI-06511h 96 Tests
EUR 988.8

Mouse Human CD80

E2790169 100ul
EUR 225
Description: Available in various conjugation types.

Recombinant Human T-lymphocyte activation antigen CD80 (CD80), partial

CSB-MP004959HU1 4892 mg Ask for price

Anti-Hu CD80 PE

1P-287-T025 25 tests
EUR 121

Anti-Hu CD80 PE

1P-287-T100 100 tests
EUR 242
  • CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation,
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Anti-Hu CD80 APC

1A-287-T025 25 tests
EUR 121

Anti-Hu CD80 APC

1A-287-T100 100 tests
EUR 242
  • CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation,
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PE anti-rat CD80

E16FRP080-050U 50 μg
EUR 390
Description: Available in various conjugation types.

Anti-Mouse CD80 Antibody

103-M144 100 µg
EUR 399
Description: B7-1 (CD80) and B7-2, together with their receptors CD28 and CTLA4, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. Although both CTLA4 and CD28 can bind to the same ligands, CTLA4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28 and is involved in the downregulation of the immune response. B7-1 is expressed on activated B cells, activated T cells, and macrophages. B7-2 is constitutively expressed on interdigitating dendritic cells, Langerhans cells, peripheral blood dendritic cells, memory B cells, and germinal center B cells. Additionally, B7-2 is expressed at low levels on monocytes and can be upregulated through interferon gamma. B7-1 and B7-2 are both members of the Immunoglobulin superfamily.

Anti-Hu CD80 FITC

1F-287-T025 25 tests
EUR 99

Anti-Hu CD80 FITC

1F-287-T100 100 tests
EUR 198
  • CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation,
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PE anti-mouse CD80

E16FMP080-050U 50 μg
EUR 405.33
Description: Available in various conjugation types.

PE anti-mouse CD80

E16FMP080-100U 100 μg
EUR 629.33
Description: Available in various conjugation types.

PE anti-mouse CD80

E16FMP080-200U 200 μg
EUR 1258.67
Description: Available in various conjugation types.

Anti-Hu CD80 PerCP

PC-287-T025 25 tests
EUR 121

Anti-Hu CD80 PerCP

PC-287-T100 100 tests
EUR 242
  • CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation,
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APC anti-mouse CD80

E16FMA080-025U 25 μg
EUR 272
Description: Available in various conjugation types.

FITC anti-mouse CD80

E16FMF080-050U 50 μg
EUR 260
Description: Available in various conjugation types.

FITC anti-mouse CD80

E16FMF080-500U 500 μg
EUR 618.67
Description: Available in various conjugation types.

Anti-Ms CD80 Purified

11-627-C100 0.1 mg
EUR 88
  • CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation,
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Anti-Hu CD80 Purified

11-287-C025 0.025 mg
EUR 77

Anti-Hu CD80 Purified

11-287-C100 0.1 mg
EUR 154
  • CD80 (B7-1) and CD86 (B7-2) are ligands of T cell critical costimulatory molecule CD28 and of an inhibitory receptor CTLA-4 (CD152). The both B7 molecules are expressed on professional antigen-presenting cells and are essential for T cell activation,
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Purified anti-rat CD80

E16FRU080-500U 500 μg
EUR 953.33
Description: Available in various conjugation types.

Biotin anti-mouse CD80

E16FMB080-050U 50 μg
EUR 281.67
Description: Available in various conjugation types.

Biotin anti-mouse CD80

E16FMB080-100U 100 μg
EUR 563.33
Description: Available in various conjugation types.

Purified anti-mouse CD80

E16FMU080-1000U 1 mg
EUR 1690
Description: Available in various conjugation types.

Purified anti-mouse CD80

E16FMU080-500U 500 μg
EUR 845
Description: Available in various conjugation types.

Cd80 (untagged) - Mouse CD80 antigen (Cd80), (10ug)

MC208260 10 µg Ask for price

OATA00554-100UG - Human CD80 Antibody

OATA00554-100UG 100ug
EUR 109
  • Human CD80 Antibody

OATA00554-500UG - Human CD80 Antibody

OATA00554-500UG 500ug
EUR 329
  • Human CD80 Antibody

OATA00264-100UG - Human CD80 Antibody

OATA00264-100UG 100ug
EUR 229
  • Human CD80 Antibody

OATA00264-500UG - Human CD80 Antibody

OATA00264-500UG 500ug
EUR 389
  • Human CD80 Antibody

Mouse anti-Human CD80, Purified mAb

E16HU080-100 100Tests
EUR 225
Description: Available in various conjugation types.

Mouse anti-Human CD80, Purified mAb

E16HU080-500 500Tests
EUR 300
Description: Available in various conjugation types.

Mouse Anti-Human CD80 mAbConjugated Antibody

CCM015 100ul
EUR 476.4

Human T-lymphocyte activation antigen CD80 / B7-1 (CD80) ELISA Kit

abx250225-96tests 96 tests
EUR 801.6
  • Shipped within 5-12 working days.

Human T-lymphocyte activation antigen CD80 / B7-1 (CD80) ELISA Kit

20-abx258485
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  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests
  • Shipped within 5-7 working days.

Mouse Human CD80 (PE)

E2790327 100ul
EUR 225
Description: Available in various conjugation types.

Human CD80 ELISA Kit

ELA-E2026h 96 Tests
EUR 988.8

Cd80 (GFP-tagged) - Mouse CD80 antigen (Cd80), (10ug)

MG227446 10 µg Ask for price

Cd80 (Myc-DDK-tagged) - Mouse CD80 antigen (Cd80)

MR227446 10 µg Ask for price

Mouse Human CD80 (FITC)

E2790249 100ul
EUR 225
Description: Available in various conjugation types.

Human CD80 shRNA Plasmid

20-abx950663
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  • 150 µg
  • 300 µg
  • Shipped within 15-20 working days.

Human B7-1/CD80

GT15255 100 ug
EUR 856.8

Human B7-1/CD80

MO15156 100 ug
EUR 700.8

Lenti ORF particles, CD80 (mGFP-tagged) - Human CD80 molecule (CD80), 200ul, >10^7 TU/mL

RC206540L2V 200 µl Ask for price

Lenti ORF particles, CD80 (mGFP-tagged) - Human CD80 molecule (CD80), 200ul, >10^7 TU/mL

RC206540L4V 200 µl Ask for price

CD80 ELISA KIT|Human

EF000069 96 Tests
EUR 826.8

CD80 (Human) ELISA Kit

K4172-100 each
EUR 874.8

Alexa Fluor® 488 anti-human CD80

E16FHG080-025 25 tests
EUR 455
Description: Available in various conjugation types.

Alexa Fluor® 488 anti-human CD80

E16FHG080-100 100 tests
EUR 975
Description: Available in various conjugation types.

Alexa Fluor® 647 anti-human CD80

E16FHK080-025 25 tests
EUR 455
Description: Available in various conjugation types.

Alexa Fluor® 647 anti-human CD80

E16FHK080-100 100 tests
EUR 975
Description: Available in various conjugation types.

OATA00341-25T - Human CD80 Antibody : PE

OATA00341-25T 25Tests
EUR 109
  • Human CD80 Antibody : PE

Lenti ORF clone of Human CD80 molecule (CD80), mGFP tagged

RC206540L2 10 µg Ask for price

Lenti ORF clone of Human CD80 molecule (CD80), mGFP tagged

RC206540L4 10 µg Ask for price

OATA00064-25T - Human CD80 Antibody : APC

OATA00064-25T 25Tests
EUR 119
  • Human CD80 Antibody : APC

OATA00341-100T - Human CD80 Antibody : PE

OATA00341-100T 100Tests
EUR 259
  • Human CD80 Antibody : PE

OATA00064-100T - Human CD80 Antibody : APC

OATA00064-100T 100Tests
EUR 279
  • Human CD80 Antibody : APC

Purified Anti-Mouse CD80 Antibody

DL20093F-100ug 100μg
EUR 242
Description: CD80 is a 60 kD highly glycosylated protein. It is a member of the Ig superfamily and is also known as B7-1, B7, and Ly-53. CD80 is constitutively expressed on dendritic cells and monocytes/macrophages, and inducibly expressed on activated B and T cells. The ligation of CD28 on T cells with CD80 and CD86 (B7-2) on antigen presenting cells (such as dendritic cells, macrophages, and B cells) elicits co-stimulation of T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD80 appears to be expressed later in the immune response than CD86. CD80 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.

Purified Anti-Mouse CD80 Antibody

DL20093F-50ug 50μg
EUR 177.5
Description: CD80 is a 60 kD highly glycosylated protein. It is a member of the Ig superfamily and is also known as B7-1, B7, and Ly-53. CD80 is constitutively expressed on dendritic cells and monocytes/macrophages, and inducibly expressed on activated B and T cells. The ligation of CD28 on T cells with CD80 and CD86 (B7-2) on antigen presenting cells (such as dendritic cells, macrophages, and B cells) elicits co-stimulation of T cells resulting in enhanced cell activation, proliferation, and cytokine production. CD80 appears to be expressed later in the immune response than CD86. CD80 can also bind to CD152, also known as CTLA-4, to deliver an inhibitory signal to T cells.

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